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 Previous Article

Clinical and Diagnostic Laboratory Immunology, January 2004, p. 229-234, Vol. 11, No. 1
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.1.229-234.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Age-Related Changes in Expression of CXCR4 and CCR5 on Peripheral Blood Leukocytes from Uninfected Infants Born to Human Immunodeficiency Virus Type 1-Infected Mothers

Sharon Shalekoff,1 Glenda E. Gray,2,3 and Caroline T. Tiemessen1*

AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology ,1 University of the Witwatersrand, Johannesburg,3 Perinatal HIV Research Unit, Chris Hani-Baragwanath Hospital, Soweto, South Africa2

Received 18 July 2003/ Returned for modification 5 September 2003/ Accepted 17 October 2003

Cross-sectional analysis of human immunodeficiency virus-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age.

* Corresponding author. Mailing address: National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, South Africa. Phone: (27-11) 321-4200. Fax: (27-11) 882-0596. E-mail: carolinet{at}nicd.ac.za.

Clinical and Diagnostic Laboratory Immunology, January 2004, p. 229-234, Vol. 11, No. 1
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.1.229-234.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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