This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kohmoto, M.
Right arrow Articles by Miyazawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kohmoto, M.
Right arrow Articles by Miyazawa, T.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, January 2003, p. 185-188, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.185-188.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Experimental Mucosal Infection with Molecularly Cloned Feline Immunodeficiency Viruses

Mariko Kohmoto,1,{dagger} Yasuhiro Ikeda,1,{ddagger} Eiji Sato,1,3 Yorihiro Nishimura,1,2 Yasuo Inoshima,1,4 Masayuki Shimojima,1 Yukinobu Tohya,1 Takeshi Mikami,1,4 and Takayuki Miyazawa1,2,3*

Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, and Host and Defence, PRESTO, Japan Science and Technology Corporation, Tachikawa, Tokyo,1 Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka,2 ,3 Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource, Nihon University, Fujisawa, Kanagawa, Japan4

Received 23 July 2002/ Returned for modification 4 September 2002/ Accepted 9 October 2002

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

* Corresponding author. Mailing address: Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-8343. Fax: 81-6-6879-8269. E-mail: takavet{at}biken.osaka-u.ac.jp.

{dagger} Present address: Pasturing Disease Section, Shichinohe Research Unit, National Institute of Animal Health, Kamikitagun, Aomori, Japan.

{ddagger} Present address: Department of Immunology, The Windeyer Institute, University College London, London, United Kingdom.

§ Present address: Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

Present address: Viral Pathogenicity Section, Department of Exotic Diseases, National Institute of Animal Health, Kodaira, Tokyo, Japan.

Clinical and Diagnostic Laboratory Immunology, January 2003, p. 185-188, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.185-188.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • D'Cruz, O. J., Waurzyniak, B., Uckun, F. M. (2004). Antiretroviral Spermicide WHI-07 Prevents Vaginal and Rectal Transmission of Feline Immunodeficiency Virus in Domestic Cats. Antimicrob. Agents Chemother. 48: 1082-1088 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»