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Clinical and Diagnostic Laboratory Immunology, January 2003, p. 180-181, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.180-181.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Immunoglobulin G Antibodies against the Endosymbionts of Filarial Nematodes (Wolbachia) in Patients with Pulmonary Dirofilariasis

F. Simón,1 G. Prieto,1 R. Morchón,1 C. Bazzocchi,2 C. Bandi,2 and C. Genchi2*

Laboratorio di Parassitologia, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain,1 Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Patologia Generale e Parassitologia, 20133 Milan, Italy2

Received 28 May 2002/ Returned for modification 7 August 2002/ Accepted 19 September 2002

The dog parasite Dirofilaria immitis can infect humans. Patients with pulmonary dirofilariasis were tested for immunoglobulin G (IgG) antibodies against the surface protein of Wolbachia, the bacterial endosymbiont of D. immitis. These patients showed significantly higher IgG titers than healthy individuals from areas in which D. immitis was endemic as well as areas in which it was not endemic. Titration of anti-Wolbachia surface protein IgG could become useful for diagnostic applications.

* Corresponding author. Mailing address: Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Patologia Generale e Parassitologia, Via Celoria 10, 20133 Milan, Italy. Phone: 39 02 50318101. Fax: 39 02 50318095. E-mail: claudio.genchi{at}unimi.it.

Clinical and Diagnostic Laboratory Immunology, January 2003, p. 180-181, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.180-181.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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