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Clinical and Diagnostic Laboratory Immunology, January 2003, p. 167-168, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.167-168.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Elevated Fecal Candida Counts in Patients with Antibiotic-Associated Diarrhea: Role of Soluble Fecal Substances

Department of Medicine, Division of Infectious Diseases, Karl-Franzens University, Graz, Austria,¹ Department of Medicine, Division of Infectious Diseases and Tropical Medicine, University Rostock, Rostock, Germany²

Received 11 July 2002/ Returned for modification 30 August 2002/ Accepted 18 September 2002

To assess the role of soluble fecal substances in the elevation of fecal Candida counts in patients with antibiotic-associated diarrhea (AAD), we investigated the growth of Candida albicans in vitro in serially diluted stool fluids from patients with AAD and healthy subjects. There were significantly higher Candida albicans counts in stool fluids diluted 1:10 from AAD patients than in healthy subjects and the phosphate-buffered saline growth control, which may be due to reduced soluble Candida inhibitors and increased availability of growth factors and nutrients.