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Clinical and Diagnostic Laboratory Immunology, Jul 1994, 401-405, Vol 1, No. 4
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

The Vitek immunodiagnostic assay for detection of immunoglobulin M toxoplasma antibodies

E Candolfi, R Ramirez, MP Hadju, C Shubert and JS Remington
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301, USA.

We compared the Vitek immunodiagnostic assay for detection of immunoglobulin M (IgM) toxoplasma antibodies (VIDAS TXM) with an IgM enzyme-linked immunosorbent assay (ELISA) which we developed. A total of 407 serum samples from 391 adults were used for this study. We also examined 17 serial serum samples from four women who had seroconverted during gestation. We observed a sensitivity of 99.5%, a specificity of 93%, a positive predictive value of 93.6%, a negative predictive value of 99.5%, and a global agreement of 96.3%. In each case of seroconversion the VIDAS TXM became positive at the same time as did the IgM ELISA.

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