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Clinical and Diagnostic Laboratory Immunology, Jul 1994, 379-384, Vol 1, No. 4
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Acute monocytic leukemia in a dog with X-linked severe combined immunodeficiency

PJ Felsburg, RL Somberg and GS Krakowka
Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania 19104, USA.

We describe the occurrence of acute monocytic leukemia in a dog with X- linked severe combined immunodeficiency (XSCID) that had been raised in a gnotobiotic environment for 20 months. This case represents the first reported instance of malignancy in canine XSCID, the first case of acute monocytic leukemia in any species with severe combined immunodeficiency, and the first documented malignancy in any species with XSCID that was not associated with immunotherapy.

This article has been cited by other articles:

• Perryman, L. E. (2004). Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs. Vet Pathol 41: 95-100 [Abstract] [Full Text]