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Clinical and Diagnostic Laboratory Immunology, 03 1994, 241-243, Vol 1, No. 2
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis

P Vannuffel, C Dieterich, B Naerhuyzen, P Gilot, M Coene, R Fiasse and C Cocito
Microbiology and Genetics Unit, University of Louvain, Brussels, Belgium.

Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.

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