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Clinical and Diagnostic Laboratory Immunology, 03 1994, 235-237, Vol 1, No. 2
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Lack of antibody response to invasin in humans with yersiniosis

N Fortineau, JL Beretti, P Berche and M Simonet
Laboratories de Microbiologie, Faculte de Medecine Necker-Enfants Malades, Paris, France.

The Yersinia pseudotuberculosis inv gene encodes invasin, a 103-kDa outer membrane protein allowing bacteria to penetrate mammalian cells. This protein is produced in vitro at below 30 degrees C. In this work, we studied the antibody response against invasin in humans suffering from yersiniosis and in mice orally infected with a virulent strain of Y. pseudotuberculosis. Infection with enteropathogenic Yersinia strains did not induce either a systemic or a gut antibody response to invasin. Our results suggest that the inv gene is not expressed in the gut at 37 degrees C and, therefore, that invasin is not present to the immune system when microorganisms multiply in the host tissues.